The Barclays FA WSL league leaders will provide a stern test for Marta Tejedor's side, who are hopeful of getting key players back from injury.
Kerys Harrop, Lucy Staniforth, Sarah Mayling, Rachel Williams and long-term absentee Heidi Logan were not available last weekend.
Blues lost to Brighton & Hove Albion and the Manager will wait on the bulletin from the Club's medical staff before deciding on the line-up.
Whoever takes to the field, however, will have to help keep a rein on the midfield area, which has been identified as a key battleground by Tejedor.
"Chelsea are a very, very good team." she said. "They are leading the table right now.
"I think if we can stop their midfield - provide a circuit cut in the midfield - then that will help our chances. You can't let them play as fluently as they like to in midfield."
Blues won their last home match, a crucial 2-0 success against Liverpool.
"We are at home, we have our support with us and, for sure, we are certainly going to work for it."
Blues called up Academy starlets Freya Gregory and Lily Simkin for Brighton, and the former made her starting debut.
Tejedor said: "To play (in the WSL) you need to be prepared physically, technically, tactically and mentally.
"It was a bit like a precipitation for them: suddenly they were in a match they were not expected to be in.
"So from that perspective it was always going to be difficult. But I was quite happy with both of them."
Gregory succumbed to cramp in the second-half, affording Simkin the opportunity to come on.
"I felt with Freya we didn't exploit her quickness that much," said Tejedor. "We tended to play to the other wing.
"We perhaps were not that used to Freya and she maybe didn't ask for the ball as much as she would usually.
"When Lily came on she also did a good job. She didn't get into trouble, she played it simply but effectively.
"Hers was not a position that could have affected the score, but she played well for the team."