Everyone is excited and more than ready for itClaudia Walker, Blues Women
And it's a tough task confronting them in the Barclays FA WSL.
Manchester have won all six of their league, cup and European matches so far this season and conceded just one goal.
But, as far as Claudia Walker is concerned, it's about Blues and what they hope to do rather than Manchester's capabilities.
It's been a frustrating two-and-a-bit weeks of kicking heels for Blues, after the postponement of the Reading Women fixture at Solihull Moors and the international break.
"It was disappointing to have Reading called off," said the striker. "We had prepared well for it and we were hopefully going to pick up our first points in the league.
"That's still the aim now going into Saturday. If anything, it's given us a bit more time to prepare and focus on what we want to get out of this game.
"It's one of the most exciting games in the league, it's the kind we all live for. You want to play against a team ranked as one of the best.
"Everyone is excited and more than ready for it.
"Even though they have new players in who may add a bit extra, a bit of their own style, basically the main things and their philosophy will be the same as it always has been.
"We know what to expect and we have just got to focus on ourselves and make sure we do as much as we possibly can to get a good result."
Become more clinical is a trait that Blues have been working on in particular since their opening two WSL matches. Blues first victory on the campaign came at the third
attempt, in the Continental Cup.
"It's in the final third, taking more of our chances," said Walker, when asked about the tweaks that have been identified for improvement.
"We are creating them, but we are getting to a point where we need to be finishing them off.
"We want more goals, as a team. We want to make sure we are upsetting other teams but getting on the scoresheet is the main aim."
And although Walker is still seeking her first strike of the campaign, she is more concerned about the greater good.
"Getting my first goal would be nice," she admitted.
"I just have got to do what I can for the team. It's more about us winning at the minute rather than who gets the goals.
"I am bothered, but it's not the sole focus. I'd rather us be winning games. If I get an assist or something and it contributes to a win, then that's fine."
As Blues news players continue to bed in as the weeks tick by, the relationship with Manager Marta Tejedor - who is now in her first full season on these shores - has grown stronger. She is happy to counsel opinion in a two-way understanding with Blues more experienced players as the adjustment to her style grows.
"We know exactly what Marta wants from us, we're settled in, so we can also start to bring our own little spin to things," said Walker.
"Obviously we have to make sure we're doing what she asks, but it's adding into it, challenging her ideas, in the right way. We have got to that stage now where the discussions happen more freely.
"She will have ideas how she wants to play but as players, as staff, as a group, we will contribute to that. It's quite nice really as everyone has their input in what we think is best
for one another."
Walker added: "In analysis, we have people like Kerys Harrop, who has played Man City God knows how many times for example, and Rachel Williams. They have different kind
of experiences and that's kind of good as some of the new girls haven't played in the WSL.
"We have to make sure we take that responsibility to educate them about the league, the certain styles of play each team has."
Walker said that the spirit between the players is a big plus.
"We're limited numbers, so it's quite a close group. But that's brought us together just a little bit more because obviously we have got to have each other's back.
"There's a good group who have come in and the ones who have stayed are great girls. We're as one."